first_imgUmphrey’s McGee are a live music juggernaut. Delivering night after night of high-octane performances, the band’s shows are filled with explosive improvisation, tight, composed sections, and their own blend of rock, metal, jazz, and jam music. Perhaps no song exemplifies Umphrey’s unique live abilities than “Utopian Fir”. The multi-sectional song is one of the band’s most reliable jam vehicles, and fans know to expect fireworks when they bust out the old, reliable favorite.When Umphrey’s performed “Utopian Fir” in at the ExploreAsheville.com Arena in Asheville, NC on 2/20/2016, it was another landmark version of the song. The band whipped the song into many different directions; first a tease of Heart‘s “Barracuda” during the song’s opening section, then a funky jam that featured guitarist Jake Cinninger hopping onto the piano with Joel Cummins for some syncopated, dual-key action. Brendan Bayliss added some psychedelic guitar licks and took over, before Cinninger eventually returned to the guitar to build up a progressive vibe before closing out the song.Watch the impressive “Utopian Fir” from 2/20/16 below, courtesy of the band themselves, and enjoy the progressive awesomeness that is Umphrey’s McGee.last_img read more

first_imgThis weekend, Phil Lesh has invited a number of heavy-hitters to join him for a special three-night Phil & Friends run at his San Rafael, California venue, Terrapin Crossroads. Spanning from June 8th to June 10th, the first two nights of the run will serve as special “Dead Blues” performances before June 10th’s more-traditional Phil & Friends show. Last night kicked off the weekend with Luther and Cody Dickinson (North Mississippi All-Stars), John Medeski, Roosevelt Collier, Junior Mack (Jaimoe’s Jasssz Band), Grahame Lesh (Midnight North, Terrapin Family Band), Danielle Nicole and Elliott Peck.Thanks to a free stream from nugs.tv, you can watch the full show below, which featured an energetic mix of Grateful Dead and blues standards, below:[Video: nugs.tv]Tonight, Grahame Lesh, the Dickinson brothers, Medeski, and Collier will return to join the former Grateful Dead bassist, in addition to Tash Neal and JD Simo for the second night of “Dead Blues.” For the final night of the run, on Sunday, Phil Lesh will perform a special Phil & Friends set featuring the Dickinson brothers, John Medeski, Anders Osborne, and a special guest.This three-night run comes ahead of Terrapin Crossroad’s Unbroken Train run, which will see Phil Lesh & Terrapin Family Band, Midnight North, and Twiddle team up in various configurations over the course of June 14th to 16th.Setlist via JamBuzz: Phil Lesh & Friends | San Rafael, CA | Terrapin Crossroads | 6/9/18I: Viola Lee Blues, Little Red Rooster, Howling wolf song?, Mr. Charlie, It Hurts Me Too, Big Boss Man, Nobody’s Fault but Mine, Death Don’t Have No MercyII : Come Together> Deep Elem Blues, Walkin’ Blues, Death Don’t Have No Mercy, Let the Good Times Roll, Mystery Train. Tomorrow Never Knows>Smokestack Lightning, Truckin’, Donor Rap, And We Bid You Goodnightlast_img read more

first_imgScientists are one step closer to a revolution in DNA sequencing, following the development in a Harvard lab of a tiny device designed to read the minute electrical changes produced when DNA strands are passed through tiny holes — called nanopores — in an electrically charged membrane.As described in Nature Nanotechnology on Dec. 11, a research team led by Charles Lieber, the Mark Hyman Jr. Professor of Chemistry, have succeeded for the first time in creating an integrated nanopore detector, a development that opens the door to the creation of devices that could use arrays of millions of the microscopic holes to sequence DNA quickly and cheaply.First described more than 15 years ago, nanopore sequencing measures subtle electrical current changes produced as the four base molecules that make up DNA pass through the pore. By reading those changes, researchers can effectively sequence DNA.But reading those subtle changes in current is far from easy. A series of challenges — from how to record the tiny changes in current to how to scale up the sequencing process — meant the process has never been possible on a large scale. Lieber and his team, however, believe they have found a unified solution to most of those problems.“Until we developed our detector, there was no way to locally measure the changes in current,” Lieber said. “Our method is ideal because it is extremely localized. We can use all the existing work that has been done on nanopores, but with a local detector we’re one step closer to completely revolutionizing sequencing.”The detector developed by Lieber and his team grew out of earlier work on nanowires. Using the ultra-thin wires as a nanoscale transistor, they are able to measure the changes in current more locally and accurately than ever before.“The nanowire transistor measures the electrical potential change at the pore and effectively amplifies the signal,” Lieber said. “In addition to a larger signal, that allows us to read things much more quickly. That’s important because DNA is so large [that] the throughput for any sequencing method needs to be high. In principle, this detector can work at gigahertz frequencies.”“The nanowire transistor measures the electrical potential change at the pore and effectively amplifies the signal,” said Charles Lieber. “In addition to a larger signal, that allows us to read things much more quickly.” File photo Kris Snibbe/Harvard Staff PhotographerThe highly localized measurement also opens the door to parallel sequencing, which uses arrays of millions of pores to speed the sequencing process dramatically.In addition to the potential for greatly improving the speed of sequencing, the new detector holds the promise of dramatically reducing the cost of DNA sequencing, said Ping Xie, an associate of the Department of Chemistry and Chemical Biology and co-author of the paper describing the research.Current sequencing methods often start with a process called the polymerase chain reaction, or DNA amplification, which copies a small amount of DNA thousands of millions of times, making it easier to sequence. Though critically important to biology, the process is expensive, requiring chemical supplies and expensive laboratory equipment.In the future, Xie said, it will be possible to build the nanopore sequencing technology onto a silicon chip, allowing doctors, researchers, or even the average person to use DNA sequencing as a diagnostic tool.The breakthrough by Lieber’s team could soon make the transition from lab to commercial product. The Harvard Office of Technology Development is working on a strategy to commercialize the technology appropriately, including licensing it to a company that plans to incorporate it into their DNA sequencing platform.“Right now, we are limited in our ability to perform DNA sequencing,” Xie said. “Current sequencing technology is where computers were in the ’50s and ’60s. It requires a lot of equipment and is very expensive. But just 50 years later, computers are everywhere, even in greeting cards. Our detector opens the door to doing a blood draw and immediately knowing what a patient is infected with, and very quickly making treatment decisions.”last_img read more

first_imgVirtually all (97 percent) of the patients who received stem cells from a matched sibling donor survived. At 50 percent, survival was lowest among patients who were older than 3½ months and had active infections at the time of transplant. Actively infected infants who did not have a matched sibling donor and who received immunosuppressive or chemotherapy before transplant had particularly poor survival rates (39-53 percent). Among patients who underwent transplant at younger than 3½ months, 94 percent survived. Children born with so-called “bubble boy” disease have the best chance of survival if they undergo a hematopoietic stem cell transplant as soon after birth as possible, according to a detailed analysis of 10 years of outcome data by researchers at the Harvard-affiliated Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. Researchers say the findings support expanding newborn screening for severe combined immune deficiency (SCID), a disorder that leaves affected infants so vulnerable to infection that most die within the first year of life if untreated.The study, published today in the New England Journal of Medicine, analyzed data on 240 children with SCID who underwent transplants at 25 centers across North America between Jan. 1, 2000, and Dec. 31, 2009, the decade before the U.S. Department of Health and Human Services recommended newborn screening for SCID in 2010. Currently, 21 states and the District of Columbia — together home to about two-thirds of all babies born in the United States — screen newborns for SCID. Another nine states are expected to implement newborn screening by the end of 2014.“The best way to identify patients that early when there is no family history of SCID [severe combined immune deficiency] is through newborn screening,” said Sung-Yun Pai, first author on the study. Photo courtesy of Dana-Farber/Boston Children’sIn addition to patient age, the analysis found that infection status at the time of transplant and donor source had the strongest impact on transplant outcomes (i.e., five-year survival and successful immune system reconstitution).“Survival is much, much better if infants undergo transplant before they turn 3½ months old and before they contract any SCID-related infections,” said study first author Sung-Yun Pai of Dana-Farber/Boston Children’s. “The best way to identify patients that early when there is no family history of SCID is through newborn screening.”Data gained from newborn screening suggest that SCID, while still rare, is twice as common as once thought. “Some children who succumbed to unexplained infections probably suffered from SCID,” Pai noted. The disorder is now estimated to occur in one of every 50,000 births, up from earlier estimates of one in 100,000.“Time is not the ally of children with SCID,” said Luigi Notarangelo of Boston Children’s Hospital, one of the study’s senior authors, who was among those who lobbied successfully to establish SCID newborn screening in Massachusetts in 2009. “Because they do not have a functional immune system, the longer the wait before a transplant, the greater the risk they will contract a potentially devastating infection.”The new study was conducted under the auspices of the Primary Immune Deficiency Treatment Consortium, a North American collaborative supported by the National Institutes of Health. It looked at the effect on outcomes of patient age, infection status, donor source, and the use of chemotherapy to condition patients prior to transplant.Children who underwent transplant before 3½ months of age had excellent survival, regardless of donor source or infection status, as did patients transplanted with the stem cells of a matched sibling donor, long recognized as the gold standard of transplants. Children outside that age group also had very good survival regardless of donor source — sibling, parent, or unrelated donor — as long as the patient did not have an active infection at the time of transplant. The effect on survival of donor type and pre-transplant conditioning was only discernible in actively infected patients.Other findings:Overall, 74 percent of the 240 patients studied survived at least five years. Among patients who never had an infection, 90 percent survived, as did 82 percent of patients whose infection had resolved before transplant.While survivors who received chemotherapy conditioning had stronger immune systems after transplant, further research is needed, Pai said, to determine whether the late effects of chemotherapy or the vulnerabilities of a weaker immune system pose the greater long-term risk.“This study accomplishes several things,” she said. “First, it creates a baseline with which to compare patient outcomes since the advent of newborn screening for SCID. Second, it provides guidance for clinicians regarding the use of chemotherapy conditioning before transplantation. Third, it highlights the relative impacts of infection status and patient age on transplant success.“Lastly, it establishes the importance of early detection and transplantation, which points to the benefit of expanding newborn screening for SCID as broadly as possible.”last_img read more

first_imgHe said 579 people arrived at the airport from abroad on the same day, most of whom were migrant workers.Read also: New regulation allows businesspeople, officials to travel despite ‘mudik’ banAs many as 351 of the total passengers came from Italy using a chartered plane while 62 came from Singapore using Garuda Airlines, 116 from Malaysia using Garuda Airlines and 60 from Qatar using Qatar Airways, Anas said.The large number of inbound travelers eventually resulted in a buildup of passengers at the airport’s international arrival terminals, as they had to undergo tests before being allowed to leave the facility.”We only have 24 medical staff and five doctors at the location to help with the testing,” Anas said as quoted by tribunnews.com. (vny)Topics : Eleven inbound travelers from Italy tested positive for the coronavirus through rapid testing at Soekarno-Hatta International Airport in Tangerang, Banten, on Friday. They were subsequently admitted to the COVID-19 emergency hospital at the former Asian Games athletes village in Kemayoran, Central Jakarta.Soekarno-Hatta Airport Health Office head Anas Maruf confirmed that the inbound travelers were “Indonesian migrant workers who worked as fishing vessel crewmen in Italy”, as reported by tribunnews.com.last_img read more

first_imgTopics : ‘Future model’ Some have accused Sweden of playing Russian roulette with citizens’ lives by allowing the virus to circulate slowly in society, with the main goal being to ensure the public healthcare system can keep pace. The consequences are difficult to miss — Sweden’s death rate stood at 371 per million inhabitants on Tuesday, roughly eight times the rate in Norway and Finland, according to the Worldometer website.However, although Sweden’s hospitals have reported strained conditions, they have not been overwhelmed. At the Danderyd Hospital in Stockholm’s north, Klara Bergmark, head of the intensive care unit, told AFP that staff may be tired, but they are preparing to work at a heightened level over the summer and potentially “the whole year”.”Endurance is very important here, to be able to do this for a long time,” Bergmark said.Sweden’s approach may be tough on some sections of society, but some experts see it as far-sighted, especially as one recent report from the University of Minnesota suggested “significant COVID-19 activity” was likely to be around for at least another two years.”If we wish to get back to a society in which we don’t have lockdowns, then society may need to adapt for a medium or potentially a longer period of time,” WHO’s emergencies chief Michael Ryan told a press conference in late April, suggesting Sweden could be a “future model”.”I think there may be lessons to be learnt from our colleagues in Sweden.”Unfazed by the criticism of Sweden’s strategy, epidemiologist Tegnell said it was still too early to say whether an initial lockdown phase in Sweden — like those in neighboring countries — would have limited its mortality rate.But he has suggested a second wave of the virus could be milder in Sweden than in countries where lockdowns were imposed.”I think the Swedish strategy has proven to be sustainable. We get figures now that people are actually increasing their adherence to our advice, not decreasing,” Tegnell said. “It’s apparently reasonably easy to start a lockdown, but stopping it is much more difficult,” state epidemiologist Anders Tegnell of the Public Health Agency told AFP.He noted the difficulty of getting people to follow recommendations when “one day you’re supposed to do this and the next you’re supposed to do something else”. The European Union has started planning for a phased restart of travel this summer but Sweden has told its residents they will have to holiday at home, extending a non-essential travel advisory until at least July 15 — the middle of the country’s main holiday month.Other restrictions on travel, sport and care-home visits are also likely to remain in place even while other countries try to re-emerge from lockdowns.However, Sweden never imposed full lockdown measures — under-16s have continued to go to school, patrons have not been stopped from going to cafes, bars and restaurants.Although people have been urged to limit contacts and practice social distancing, the restrictions are advisory. Sweden has taken a soft approach to virus restrictions and although its rules are likely to be in place longer than in other countries, officials are adamant their strategy is a winner in the long term.”This fight against COVID-19 is a marathon,” Prime Minister Stefan Lofven said recently, adding that his officials “strongly believe” their measures are viable for the long haul.While people in other European countries have gradually begun returning to their workplaces in recent weeks, Swedes have been strongly advised to continue working from home, and possibly not just for weeks, but for months to come.last_img read more

first_imgStill awaiting green light The Premier League on Thursday announced the date of June 17 for its return, although that remains “provisional” for now, according to chief executive Richard Masters.He admitted the date “cannot be confirmed until we have met all the safety requirements needed, as the health and welfare of all participants and supporters is our priority.”Meanwhile, the Swiss league will vote on Friday whether to give the green light for a resumption on June 20. With Italy’s Serie A on Thursday setting a date for its return from the coronavirus shutdown and the English Premier League also now agreed on when to resume, AFP Sport casts a glance at the situation for football leagues across Europe:Leagues restarting The German Bundesliga was the first major European league to return on May 16, but the Faroe Islands came back before that. Football is also being played again in Estonia, the Czech Republic and Hungary, while Belarus was the one country on the continent where it never went away during the coronavirus crisis. Season overThe Netherlands was the first European country to bring an early end to the season on April 24 as the Eredivisie was cancelled without a champion being crowned.France then followed suit on April 30, ending the season with 10 rounds of matches unplayed.The season was not voided, though, with Paris Saint-Germain confirmed as champions, European places dished out and relegation and promotion between the top two divisions maintained on a two-up, two-down basis.Belgium also ended its season, with Club Brugge champions, after the Belgian government announced it was suspending all sporting competitions until July 31.In Scotland the season had already been called early in the three divisions below the top flight and the Premiership followed suit on May 18, with Celtic being crowned champions for the ninth year running.Luxembourg and Cyprus also called an end to their seasons but without naming a champion. Serbia, Ukraine — May 30Austria — June 2Portugal — June 3Slovenia — June 5Croatia, Greece — June 6Spain — week beginning June 8Turkey — June 12Norway — June 16Italy — June 20Russia — June 21Finland — July 1center_img On Thursday, Italy’s sports minister confirmed that Serie A will return on June 20, while La Liga in Spain will resume its season in the week beginning June 8.Here are confirmed restart dates elsewhere:Denmark — May 28Poland — May 29 Topics :last_img read more

first_img “I have to be honest with myself. It’s the most important thing so I have to appeal,” Mourinho said. “The moment we got the written reasons and I decided to appeal is the moment to stop with my opinions and not to add anything more than I did already. “I think I was very objective in my sadness facing the situation.” Mourinho on Thursday night addressed the sanction, which was announced by the FA on Wednesday. “Every word I say is a big risk for me,” he said on Thursday. “I am happy that I don’t have an electronic tag. I think it’s not far from (that). “I also think that £50,000 in the world where we live today is an absolute disgrace. “And I also think that the possibility of getting a stadium ban is also something absolutely astonishing.” Chelsea manager Jose Mourinho will appeal against the Football Association’s £50,000 fine and one-match suspended stadium ban, saying: “I have to be honest with myself.” Press Association The stadium ban will be imposed if Mourinho speaks out of turn in the next 12 months, but it is understood the FA is unlikely to pursue Thursday night’s comments. Mourinho has previously spoken of a wish to manage England – something which seems far-fetched now, given his fractious relationship with the FA. And in responding to a question on whether that possibility remains, Mourinho could not resist aiming another dig at Arsene Wenger. The Arsenal manager went unpunished for calling referee Mike Dean “weak” and “naive”, and Mourinho has repeatedly hit out at perceived inconsistencies in the disciplinary process. “Maybe I am naive – and I know that ‘naive’, I can use that word – but, for me, English football, English football fans, the English passion for the game, what makes me like so much this country and the football in this country – is not the FA,” Mourinho said. “It’s the people. If, one day, I have to work for that people, I will.” A more immediate matter is finding solutions for Chelsea’s current run of four wins in eight Premier League games, which leaves them 16th in the table. Mourinho said: “(On Friday) we had a good conversation again. We laugh a lot because Diego Costa found the reasons for the bad results. “I cannot tell you (but) he gave us the solution to go back to victories.” Mourinho lost one of 100 Premier League home games, but has now lost two in his last three after the Southampton defeat. The Portuguese admits playing at the champions’ Stamford Bridge home is a less daunting than it once was. “I really believe that every team that comes now to Stamford Bridge, they don’t fear us, they feel that they can get a result,” Mourinho said. “It’s normal. One thing is to go to a stadium where you know there’s a huge percentage of defeats for the away team. “Another is to go to a stadium where you know in the last four matches the home team only won once.” Mourinho is defiant in his belief Chelsea will climb up the table – and Villa’s record at Stamford Bridge is one win in 13 Premier League games. “We cannot run away from the reality of the table in the Premier League,” Mourinho said. “Obviously we know that we’re not going to be relegated, we know that in a couple of months we will be in a position where we normally have to be. “But the reality now, today, tomorrow before the game starts is the reality of the numbers and the numbers are very cruel, but objective and we need points.” Mourinho also believes Villa have the quality to climb out of their predicament. “A team that the manager is trying to rebuild having lost probably their two most important players of the team (Christian Benteke and Fabian Delph),” he said. “I don’t believe Aston Villa will be in this position in a couple of months.” Striker Costa is available again, after serving a three-match retrospective ban for violent conduct, but right-back Branislav Ivanovic is out after suffering a hamstring injury on Serbia duty. Mourinho is relishing the forthcoming busy period. “If we are not very well individually and collectively, I think play and play and play again is the best thing that can happen,” he said. Mourinho was sanctioned for comments made following the October 3 loss to Southampton in which he said referee Robert Madeley was “afraid” to give the Blues a penalty. The Portuguese on Friday confirmed he had received the FA’s written reasons and will appeal. last_img read more

first_imgMadrid, July 30 : American tennis player John Isner beat compatriot Ryan Harrison 5-7,6-3, 6-4 in a two hour final to win the Atlanta Open.In the first set, the 6 ft 8 inches (2.08 meters) tall Isner, ranked 9th in the ATP World ranking, on Sunday served eight aces as compared to Harrison’s four, and won more points in both his first serve (24 percent) and second serve (50 percent) than Isner, who managed 13 and 20 percent respectively, reports Efe.John, who won the tournament for the fifth time in six years, took the lead in the following two sets, kept up his service game without allowing Harrison to break him and improved his accuracy to win the tournament. IANSlast_img